{"id":16171,"date":"2018-10-01T22:34:30","date_gmt":"2018-10-01T20:34:30","guid":{"rendered":"https:\/\/www.glucotab.at\/?p=16171"},"modified":"2022-11-24T16:03:38","modified_gmt":"2022-11-24T14:03:38","slug":"feasibility-and-safety-of-using-an-automated-decision-support-system-for-insulin-therapy-in-the-treatment-of-steroid-induced-hyperglycemia-in-patients-with-acute-graft-versus-host-disease-a-randomize","status":"publish","type":"post","link":"https:\/\/www.glucotab.at\/en\/feasibility-and-safety-of-using-an-automated-decision-support-system-for-insulin-therapy-in-the-treatment-of-steroid-induced-hyperglycemia-in-patients-with-acute-graft-versus-host-disease-a-randomize\/","title":{"rendered":"Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A randomized trial"},"content":{"rendered":"<p><em>J Diabetes Investig<\/em>. 2019;10(2):339-342.<\/p>\n<p><a href=\"https:\/\/dx.doi.org\/10.1111\/jdi.12919\">https:\/\/dx.doi.org\/10.1111\/jdi.12919<\/a><!--more--><\/p>\n<p>Steroid-induced hyperglycemia (SIHG) has shown to independently increase the risk for mortality in patients with acute graft-versus-host disease, and it is still unclear whether SIHG might be a modifiable risk factor. Therefore, a feasibility trial was carried out aiming to evaluate the performance of a standardized decision support system (GlucoTab [GT]) for insulin therapy in patients with SIHG. A total of 10 hyperglycemic acute graft-versus-host disease patients were included and treated either with GT or standard of care during hospitalization. Follow-up duration was 6 months. Comparing the GT versus standard of care group, 364 versus 1,020 glucose readings were available during a median of 41 days (interquartile range [IQR] 22-89) and 101 days (IQR 55-147) of hospitalization. The median overall glucose levels were 151 mg\/dL (123-192) versus 162 mg\/dL (IQR 138-193) for GT and standard of care, respectively (P &lt; 0.001); hypoglycemia rates were comparably low. Treatment of SIHG with an algorithm-based system for subcutaneous insulin was feasible and safe.<\/p>\n<p><strong>Authors<\/strong><\/p>\n<p>Felix Aberer (1), Julia K Mader (1), Julia Holzgruber (1), Christian Trummer (1), Verena Schwetz (1), Marlene Pandis (1), Peter N Pferschy (1), Hildegard Greinix (2), Norbert J Tripolt (1), Thomas R Pieber (1, 3, 4), Armin Zebisch (2), Heinz Sill (2), Albert W\u00f6lfler (2, 3), Harald Sourij (1, 3)<\/p>\n<p><strong>Affiliations<\/strong><\/p>\n<ol>\n<li>Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.<\/li>\n<li>Division of Hematology, Medical University of Graz, Graz, Austria.<\/li>\n<li>Center for Biomarker Research in Medicine (CBmed), Graz, Austria.<\/li>\n<li>Health-Institute for Biomedicine and Health Sciences, Graz, Austria.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>J Diabetes Investig. 2019;10(2):339-342. https:\/\/dx.doi.org\/10.1111\/jdi.12919<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-16171","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/posts\/16171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/comments?post=16171"}],"version-history":[{"count":2,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/posts\/16171\/revisions"}],"predecessor-version":[{"id":18007,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/posts\/16171\/revisions\/18007"}],"wp:attachment":[{"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/media?parent=16171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/categories?post=16171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.glucotab.at\/en\/wp-json\/wp\/v2\/tags?post=16171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}